Assoc Professor Samantha Richardson
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Position |
Associate Professor |
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School / |
Medical Sciences |
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Contact Details |
+(61 3) 9925 7897 |
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Location |
Building: 201 |
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College/Portfolio |
Science, Engineering & Health |

Qualifications
- PhD (Biochemistry and Molecular Biology), University of Melbourne, 1995
- BSc (Hons), University of Melbourne, 1990
Summary of responsibilities
School level
- Postgraduate Student Coordinator
- Seminar Coordinator
- Editor (for DEEWR publications)
- Chair, Postgraduate Research Committee
- Member, School Research Committee
- Member, OH&S Committee
College level
- School representative on the SEH Higher Degrees by Research Committee
- Member, International Working Group
University level
- College representative on School of Graduate Research Advisory Board
- College representative on SGR Working Party on Increasing HDR Student Privileges
- College representative on Scholarships and RTS Subcommittee
- School representative on Animal Ethics Committee
Research interests
View Dr Richardson's research page
- Mechanisms of amyloid formation: bounding ahead using wallabies
- Regulation of adult neural stem cells by thyroid hormone
- Evolution of transthyretin structure and function
- The role of thyroid hormone distributor proteins during development
- Marsupial models of spinal cord regeneration
Industry / profession / community involvement
Membership of Professional Societies
- Australian Society for Biochemistry and Molecular Biology
- Victorian State Representative 2002-2004
- Representative at Science Meets Parliament Day 1999-2003
- Australian and New Zealand Society for Comparative Physiology and Biochemistry
- European Society for Comparative Endocrinology
- Australian Neuroscience Society
Editorial Board Membership
- Biochemical Journal
- Physiological and Biochemical Zoology
- The Australian Biochemist
- The Open Evolution Journal
- Current Proteomics
Peer Review Duties
Grant assessor (since 2005)
- Australian Research Council
- National Health and Medical Research Council
- Research Foundation Flanders
- Portuguese Science and Technology Foundation
- National Science Foundation (USA)
Reviewer for journal articles (~8 per year)
- American Journal of Physiology
- Biochemical Journal
- FEBS Journal
- General and Comparative Endocrinology
- Genes, Development and Evolution
- Journal of Comparative Physiology
- Journal of Endocrinology
- Molecular and Cellular Endocrinology
- Proteomics
- etc
Research publications since 2005
Refereed Journal Articles
- Monk JA, Sims NA, Dziegielewska KM, Weiss RE, Ramsay RG and Richardson SJ (2011) Delayed development of specific thryoid hormone-regulated events in transthyretin null mice. (submitted).
- NoorNM, SteerDL, WheatonBJ, EkCJ,Truettner JS, DietrichWD, DziegielewskaKM, Richardson SJ, SmithAI, VandeBergJL, SaundersNR(2011) Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphisdomestica). (submitted).
- Fini JB, Le Mével S, Palmier K, Darras V, Clerget-Froidevaux M-S, Richardson SJ and Demeneix BA (2011) The flame retardant TBBPA disrupts thyroid hormone signaling and neurogenesis in Xenopus embryos. (revised version in preparation).
- Hennebry SC, Sait LC, Mantena R, Humphrey TJ, Yang J, Richardson SJ and Strugnell RA (2011) Transthyretin-like protein is required for Salmonella typhimurium host-specific disease. (revised version in preparation)
- Stevenson WS, Hyland CD, Zhang G-J, Morgan PO, Willson TA, Gill A, Hilton AA, Viney EM, Bahlo M, Masters SL, Hennebry SC, Richardson SJ, Nicola NA, Metcalf D, Hilton DJ, Roberts AW and Alexander WS (2010) Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice Proc Nat Acad Sci USA 16625-16630.
- Liu Y, Ibrahim AS, Tay B-H, Richardson SJ, Bell J, Walker TI, Brenner S, Venkatesh B and Danks JA (2010) Parathyroid hormone gene family in a cartilaginous fish, the elephant shark (Callorhinchusmilii). J Bone Min Res 25:2337-2347.
- Richardson SJ, Lemkine GF, Alfama G, Hassani Z and Demeneix BA (2007) Cell division and apoptosis in the neural stem cell niche are differentially affected in transthyretin null mice. NeurosciLett 421:234-238.
- Prapunpoj P, Leelawatwatana L, Schreiber G and Richardson SJ (2006): Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3. FEBS J 273:4013-4023.
- Hennebry SC, Law RH, Richardson SJ, Buckle AM, and Whisstock JC (2006) The crystal structure of the transthyretin-like protein from Salmonella dublin a prokaryote 5-hydroxyisourate hydrolase. J Mol Biol 359:1389-1399.
- Hennebry SC, Wright HM, Likic V and Richardson SJ (2006). Structural and functional evolution of transthyretin and transthyretin-like proteins. Proteins: Struct, Funct Bioinformat. 64:1024-1045.
- Richardson SJ, Monk JA, Shepherdley CA, Ebbesson LO, Sin F, Power DM, Frappell PB, Köhrle J and Renfree MB. (2005) Developmentally regulated thyroid hormone distributor proteins in marsupials, reptile and fish. Am. J. Physiol. 288:R1264-R1272.
- Hou X, Richardson SJ, Aguilar M-I and Small DH. (2005) Binding of amyloidogenic transthyretin to the plasma membrane alters membrane fluidity and induces neurotoxicity. Biochem. 44:11618-11627.
Reviews
- Danks JA, D’Souza DG, Gunn HJ, Milley KM, Richardson SJ (2011) Evolution of the parathyroid hormone gene family and skeletal formation pathways. Gen. Comp. Endocrinol. Invited review for 50th Anniversary edition. 170:79-91.
- Richardson SJ (2009) Evolutionary changes to transthyretin: evolution of transthyretin biosynthesis. FEBS J. 276:5342-5356.
- Richardson SJ (2008) Marsupial models of thyroid hormone metabolism. Mol Cell Endcrinol. 293:32-42.
- Naylor R, Richardson SJ and McAllan BM (2008) Boom and bust: A review of the physiological life history pattern in the marsupial genus Antechinus.J. Comp. Physiol. 178:545-62.
- Richardson SJ. (2007) Cell and molecular biology of transthyretin and thyroid hormones. Int. Rev. Cytology. 258:137-193.
- Richardson SJ, Almeida OFX and Demeneix BA (2007) Hormones and adult neurogenesis in mammals. Expert Rev EndocrinolMetab. 2:261-276.
- Richardson SJ, Power DM and Klaren P (2007) Editorial foreword. Comparative thyroid endocrinology. Gen. Comp. Endocrinol. 152:176-177.
- Richardson SJ, Hennebry SC, Smith BJ and Wright HM (2005) Evolution of the thyroid hormone distributor protein transthyretin in microbes, C.elegans and vertebrates. Ann. New York Acad. Sci. 1040:448-451.
Book Chapters
- Danks JA and Richardson SJ (2011) Endocrinology and evolution: Lessons from comparative endocrinology. In: "Oxford Textbook of Endocrinology and Diabetes". 2nd Edn. Wass J and Stewart P eds. Oxford University Press, Oxford. Pp 14-23.
- McAllan BM and Richardson SJ (2010) Marsupials as models for development, aging and disease: a neurobiological and comparative context. In: "Neurobiology of Australian Marsupials" Ashwell KWS ed. Cambridge University Press.. pp 225-237.
- Richardson SJ (2009) Tissue specificity of TTR synthesis in development and evolution. In: "Recent Advances in Transthyretin Evolution, Structure and Biological Functions". Richardson SJ and Cody V eds. Springer Verlag. Berlin. pp 23-43.
- Altland K and Richardson SJ (2009) Histidine 31: The Achilles heel of human transthyretin. Microheterogeneity is not enough to understand the molecular causes of amyloidogenicity. In: "Recent Advances in Transthyretin Evolution, Structure and Biological Functions". Richardson SJ and Cody V eds. Springer Verlag. Berlin. pp 201-214.
- Monk JA and Richardson SJ (2009) Transthyretin null mice: developmental phenotypes. In: "Recent Advances in Transthyretin Evolution, Structure and Biological Functions". Richardson SJ and Cody V eds. Springer Verlag. Berlin. pp 297-310.
- Richardson SJ (2005) Expression of Transthyretin in the Choroid Plexus: Relationship to Brain Homeostasis of Thyroid Hormones. In: "The Blood-Cerebrospinal Fluid Barrier". Zheng W and Chodobski A. eds. CRC Press. Boca Raton. pp 275-304.
Awards
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2011 |
Australian Academy of Science, Scientific Visit to Japan Grant Invited Speaker- 27th Kumamoto Biomedical Symposium, Japan |
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2010 – 2012 |
ARC Discovery Grant |
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2009 |
Invited speaker: 16th International Congress of Comparative Endocrinology, Hong Kong |
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2007 – 2010 |
Victorian Neurotrauma Initiative Grant |
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2004 |
Australian Academy of Science, Scientific Visit to Europe Grant |
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2002 |
Invited speaker: 1st International Congress on Transthyretin in Health and Disease, Strasbourg |
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2001 – 2005 |
ARC Australian Research Fellowship ARC Large Grant |
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2001 |
Edgeworth David Medal (Royal Society of New South Wales) Australian Academy of Science Young Researcher Award to attend Forum for European-Australian Science and Technology Conference |
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2000 |
Australian Academy of Science Technology Diffusion Program Award for Young Researchers to attend the Symposium on Australia’s Scientific Future |
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1998 – 2000 |
ARC Australian Postdoctoral Research Fellowship ARC Large Grant |
