Professor Denise Jackson

Position

Discipline Head Laboratory Medicine

School /
Work Unit

Medical Sciences

Contact Details

+(61 3) 9925 7392

denise.jackson@rmit.edu.au

Location

Building: 223
Level: 2
Room: 1D

Bundoora West Campus

College/Portfolio

Science, Engineering & Health

Denise Jackson

Summary of responsibilities

Professor Denise Jackson is the Discipline Head of Laboratory Medicine at RMIT University, Bundoora West Campus. She is Head of the Thrombosis and Vascular Biology laboratory and is also an Honorary NHMRC fellow.

Prof. Jackson's responsibilities include:

  • Discipline Head of Laboratory Medicine
  • Member of Program Advisory Committee for Laboratory Medicine
  • Foster innovation in teaching and learning and improve teaching quality.
  • Implement "Program Experience Portfolio".
  • Maintain IBMS and AIMS accreditation of Lab Medicine courses.
  • Investigate and develop new postgraduate degrees.
  • Restructure programs to give students more flexibility.
  • Maintain liaison, collaboration and engagement with industry.
  • Investigate off-shore opportunities and develop business cases.

Qualifications

  • B. App. Sc. (MLS), RMIT, 1982
  • FAIMS, Fellow of the Australian Institute of Medical Scientists, 1989
  • PhD, Monash University, 1994

Teaching responsibilities

  • Course coordinator of MEDS1142 Medical informatics, BUSM3220 Medical laboratory quality systems and accreditation and ONPS2153 Medical informatics and laboratory management.
  • Principal supervisor of research students: Honours, Masters and PhD.

Research interests

Research in the Thrombosis and Vascular Diseases Research group aims to understand the cellular mechanisms of how blood clots are formed and what leads to stabilisation of blood clots. The research of Associate Professor Jackson and her team ranges from work on the cellular, molecular, physiological and biochemical aspects of thrombosis, to small animal models of in vivo thrombus formation and ischaemic stroke. In addition, research of this team examines the importance of cell surface receptors known as immunoreceptors in infection and immunity, with a particular emphasis on bacterial pathogens.

Research objectives

  • To study mechanisms that regulate platelet thrombus formation in mouse models.
  • To study immunoreceptors in the immune system in our established models.
  • Develop a new understanding on how immunoreceptors recognise and process bacterial pathogens to regulate immunity.
  • To gain knowledge on the importance of tetraspanins and immunoreceptors in regulating blood clots.
  • To study mechanisms of signaling and compartmentalisation in platelet responsiveness.
  • To obtain crystal structures of immunoreceptors and use this information to design drugs.

Industry / profession / community involvement

  • Reviewed project grant applications for the following funding bodies and organisations:
    • National Health and Medical Research Council
    • National Heart Foundation
    • Women's and Children's Hospital, Adelaide. S.A.
    • Fellowship Reviews, Monash University, Vic.
    • Wellcome Trust, UK.
    • National Science Foundation, USA.
  • NATA reviewer of Haematology / Immunohaematology laboratories
  • Scientific Reviewer for the following journals
    • Australian Institute of Medical Science Journal
    • Nature
    • Blood
    • Thrombosis and Haemostasis
    • Journal of Immunology
    • Journal of Histochemistry and Cytochemistry
    • Journal of Leukocyte Biology
    • Journal of Clinical Investigation
    • Cell Death and Differentiation
    • American Journal of Respiratory Cell and Molecular Biology

Professional affiliations

  • Australian Institute of Medical Scientists
  • Haematology Society of Australia
  • American Society of Hematology
  • American Society of Cell Biology
  • Australian Vascular Biology Society
  • Australian Society for Biochemistry and Molecular Biology
  • National Association of Research Fellows
  • Australian Society of Immunology
  • Member of the International Advisory Board for the XXth Congress of ISTH
  • Brain Foundation
  • ISTH

Educational development work

  • Course coordinator of MEDS1142 Medical informatics, BUSM3220 Medical laboratory quality systems and accreditation and ONPS2153 Medical informatics and laboratory management.
  • Principal supervisor of research students: 12 Honours, 3 Masters and 4 PhD.
  • Self assessment in Haematology programmes (AIMS).

Research publications

* Most recent of 42

  • Wee JL and Jackson DE. The Ig-ITIM superfamily member, PECAM-1 regulates the ‘outside-in' signalling properties of integrin alphaIIbeta3 in platelets. Blood 2005;106:3816-3823. [Impact factor: 10.131]. (Citations: 8).
  • Sardjono CT, Harbour SN, Yip JC, Paddock C, Tridandapani S, Newman PJ and Jackson DE. Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection. Thromb. Haemost. 2006;96(6):756-766.
  • Wee JL and Jackson DE. Phosphotyrosine signalling in platelets-Lessons for vascular thrombosis. Current Drug Targets 2006;7(10):1265-1273. (Citations: 2).
  • Wong MX, Hayball JD and Jackson DE. PECAM-1-regulated signaling thresholds control tolerance in anergic transgenic B cells. Mol. Immunol. 2008;45:1767-1781. [Impact factor: 4.768].
  • Goschnick M, Lau LM, Wee JL, Hogarth PM, Robb LM, Wright MD and Jackson DE. Impaired ‘outside-in' integrin αIIb3 signalling and thrombus stability in TSSC6-deficient mice. Blood 2006;Sept 15 108(6):1911-1918. [Impact factor: 10.37]. (Citations: 9).
  • Orlowski E, Chand R, Yip J, Wong C, Goschnick MW, Wright MD, Ashman LK and Jackson DE. A platelet tetraspanin superfamily member, CD151, is required for thrombus growth and stability in vivo. J Thromb. Haemost. 2009; Sept 9:7(12):2074-2084. [Impact factor: 6.29].
  • Wong C, Liu Y, Yip J, Chand R, Wee JL, Oates L, Nieswandt B, Rehemann A, Ni H, Beauchemin N and Jackson DE. CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood 2009;113:1818-1828. [Impact factor: 10.80]. Blood First Edition Paper, prepublished online November 13, 2008; DOI 10.1182/blood-2008-06-165043
  • Goschnick MW and Jackson DE. Tetraspanins-Structural and signaling scaffolds that regulate platelet function. Minireviews in Medicinal Chemistry 2007;7:1236-1247. [Impact factor: 3.15].
  • Harris K and Jackson DE. Unravelling the complicated networks of integrin αIIb3 signalling in platelets. Current Signal Transduction Therapy 2008;3(3);158-167.
  • Jackson DE. Affairs of the heart. IMPACT Bulletin, Macpharlane Burnet Institute, 2008.
  • Linden MD and Jackson DE. The role of platelets in atherogenesis. Cells in Review 2010; "In press". (In focus review).